4-Fluoro-3-(trifluoromethyl)benzonitrile → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile

HRID 1961427

反応式

HRID 1961427 の反応式
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][S:15]([O-:17])=[O:16].[Na+]>CS(C)=O.O>[CH3:14][S:15]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11])(=[O:17])=[O:16]

参加物

5

反応物 2

HCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 2733271Sodium methanesulfinate

生成物 1

HCID 459337164-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

4-Fluoro-3-(trifluoromethyl)benzonitrile (400 mg, 2.12 mmol) was suspended together with sodium methanesulfinate (216 mg, 2.12 mmol) in DMSO (2 ml) and stirred at 80° C. for 22 hours. The reaction was then cooled, diluted with 25 ml H2O and filtered. Filtered solids were evaporated from toluene to give 536 mg of the title substance (quant).

後処理

  1. temperatureThe reaction was then cooled
  2. filtrationfiltered
  3. filtrationFiltered solids
  4. customwere evaporated from toluene
  5. customto give 536 mg of the title substance (quant)

出典と根拠

ORDレコード
ord-25131b47e8044a0abb5bb5e600f8a7d5
出典データセット
uspto-grants-2013_04
特許番号
US08415333B2

関連ノート

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