関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluoro-3-(trifluoromethyl)benzonitrile | HCID 144255 | — |
| 反応物 | Sodium methanesulfinate | HCID 2733271 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile | HCID 45933716 | — |
反応手順
4-Fluoro-3-(trifluoromethyl)benzonitrile (400 mg, 2.12 mmol) was suspended together with sodium methanesulfinate (216 mg, 2.12 mmol) in DMSO (2 ml) and stirred at 80° C. for 22 hours. The reaction was then cooled, diluted with 25 ml H2O and filtered. Filtered solids were evaporated from toluene to give 536 mg of the title substance (quant).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08415333B2 |
|---|
| 出典データセット | uspto-grants-2013_04 |
|---|
| ORD ID | ord-25131b47e8044a0abb5bb5e600f8a7d5 |
|---|
| 出典メモ | uspto-grants-2013_04 |
|---|
