4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile → 4-(Tetrahydro-2H-pyran-4-yl)benzonitrile
反応式
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1>CCO.[Pd]>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1参加物
4
実験手順
450 mg (2.43 mmol) 4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile was dissolved in 15 ml EtOH and 50 mg 10% Pd/C was added. The reaction mixture was stirred under H2 (4 bar) over night at room temperature. The mixture was filtered through celite with EtOAc washing. The filtrate was concentrated and the crude product 340 mg (75% yield) was used directly in the next step.
後処理
- filtrationThe mixture was filtered through celite with EtOAc washing
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-aa96eb4e222b42e7a2776e7850b6b75c
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415333B2
反応ノート
読み込み中…