Hydrochloric Acid → (4-(tetrahydro-2H-pyran-4-yl)phenyl)methanamine
反応式
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[BH4-].[Na+].Cl>C(OCC)C.Cl[Ni]Cl>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:8]=[CH:9][C:10]([CH2:11][NH2:12])=[CH:13][CH:14]=2)[CH2:3][CH2:2]1参加物
6
実験手順
340 mg (1.82 mmol) 4-(tetrahydro-2H-pyran-4-yl)benzonitrile was reduced according to the general procedure with NiCl2 and NaBH4. The intermediate Boc-protected amine was treated with 2M HCl in diethyl ether to remove the Boc group. The crude was treated with aqueous NaHCO3 and extracted with CH2Cl2 to afford after drying and evaporation 234 mg (67%) of the title compound as an oil.
後処理
- customto remove the Boc group
- additionThe crude was treated with aqueous NaHCO3
- extractionextracted with CH2Cl2
- customto afford
- customafter drying
- customevaporation 234 mg (67%) of the title compound as an oil
出典と根拠
- ORDレコード
- ord-cb02278ac7bc4603b1ee21a0a2d30466
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415333B2
反応ノート
読み込み中…