Sodium Hydroxide → 2-(Methylamino)-1,8-naphthyridine-3-carboxylic acid

HRID 1961448ノート

反応式

HRID 1961448 の反応式
[CH3:1][NH:2][C:3]1[C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[OH-].[Na+]>CCO>[CH3:1][NH:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66745462Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate

生成物 1

HCID 666337022-(Methylamino)-1,8-naphthyridine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate (58 mg, 0.25 mmol) was dissolved in EtOH. NaOH (0.75 ml, 1M aqueous solution) was added to the solution and the mixture stirred at 40° C. for 5.0 h. The organic solvent was removed under vacuo. The remaining aqueous residue was treated with HCl (1M aqueous solution) until slightly acidic and the product extracted with EtOAc. The combined organic phases were dried over MgSO4, filtered and concentrated yielding 50.0 mg (quant) of the title compound.

後処理

  1. customThe organic solvent was removed under vacuo
  2. additionThe remaining aqueous residue was treated with HCl (1M aqueous solution) until slightly acidic and the product
  3. extractionextracted with EtOAc
  4. dry with materialThe combined organic phases were dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-88513ff0f3f642b6af055c6c60df398f
出典データセット
uspto-grants-2013_04
特許番号
US08415333B2

反応ノート

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