6-(benzyloxy)-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide → N-(4-tert-Butylbenzyl)-6-hydroxy-2-methyl-1,8-naphthyridine-3-carboxamide

HRID 1961478ノート

反応式

HRID 1961478 の反応式
C([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[N:17][CH:18]=1)[N:15]=[C:14]([CH3:19])[C:13]([C:20]([NH:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=1)=[O:21])=[CH:12]2)C1C=CC=CC=1>CO.[Pd]>[C:30]([C:27]1[CH:26]=[CH:25][C:24]([CH2:23][NH:22][C:20]([C:13]2[C:14]([CH3:19])=[N:15][C:16]3[C:11]([CH:12]=2)=[CH:10][C:9]([OH:8])=[CH:18][N:17]=3)=[O:21])=[CH:29][CH:28]=1)([CH3:33])([CH3:31])[CH3:32]

参加物

4

反応物 1

HCID 667454906-(benzyloxy)-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide

生成物 1

HCID 66745406N-(4-tert-Butylbenzyl)-6-hydroxy-2-methyl-1,8-naphthyridine-3-carboxamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

6-(Benzyloxy)-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide (62.0 mg, 0.14 mmol) was dissolved in MeOH (2 ml). Pd (C) (3.1 mg) was added to the solution. The mixture was hydrogenated at atmospheric pressure for 24 h. Then it was filtered through a pad of celite and concentrated under reduced pressure. The residue was washed with CH2Cl2 yielding 37 mg (76%) of the title compound.

後処理

  1. filtrationThen it was filtered through a pad of celite
  2. concentrationconcentrated under reduced pressure
  3. washThe residue was washed with CH2Cl2 yielding 37 mg (76%) of the title compound

出典と根拠

ORDレコード
ord-cfb91ff860be49cfa1fe0c129da0799e
出典データセット
uspto-grants-2013_04
特許番号
US08415333B2

反応ノート

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