Water → N-(2,2-difluoroethyl)-2-nitroaniline

HRID 1961557

反応式

HRID 1961557 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][CH:12]([F:15])[CH2:13][NH2:14].O>C(#N)C>[F:11][CH:12]([F:15])[CH2:13][NH:14][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]

参加物

5

反応物 3

HCID 962WaterHCID 69451-Chloro-2-nitrobenzeneHCID 1362742,2-Difluoroethanamine

生成物 1

HCID 58110950N-(2,2-difluoroethyl)-2-nitroaniline収率 95%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2 ml (19 mM) of 2-Chloronitrobenzene and 2,7 ml (36 mM) of 2,2-difluoroethyl amine in 2 ml of acetonitrile were refluxed under stirring for 24 h. Water was added and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed under vacuum to give 3,65 g of N-(2,2-difluoroethyl)-2-nitroaniline as an orange solid. Yield: 95%.

後処理

  1. extractionthe aqueous layer was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-5777d86b5f684bf1a22cf4f9563d3f94
出典データセット
uspto-grants-2013_04
特許番号
US08415352B2

関連ノート

読み込み中…