Sodium Hydroxide → 2-(5-Bromo-4-fluoro-2-methylphenyl)acetic acid

HRID 1962374ノート

反応式

HRID 1962374 の反応式
C[O:2][C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[C:9]([Br:11])[C:8]([F:12])=[CH:7][C:6]=1[CH3:13].[OH-].[Na+]>CO>[Br:11][C:9]1[C:8]([F:12])=[CH:7][C:6]([CH3:13])=[C:5]([CH2:4][C:3]([OH:14])=[O:2])[CH:10]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59614585(5-Bromo-4-fluoro-2-methyl-phenyl)-acetic acid methyl ester

生成物 1

HCID 596146012-(5-Bromo-4-fluoro-2-methylphenyl)acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of (5-bromo-4-fluoro-2-methyl-phenyl)-acetic acid methyl ester (10.3 g) in methanol (50 ml) was added 1N aqueous sodium hydroxide (47.4 ml) and the reaction mixture was stirred at room temperature for 18 hours. The mixture was concentrated, the residue treated with 1N hydrochloric acid, the resulting precipitate filtered off, washed with ice-water and dried. Yield: 8.60 g of (5-bromo-4-fluoro-2-methyl-phenyl)-acetic acid as a solid, mp: 100-101° C.

後処理

  1. concentrationThe mixture was concentrated
  2. additionthe residue treated with 1N hydrochloric acid
  3. filtrationthe resulting precipitate filtered off
  4. washwashed with ice-water
  5. customdried

出典と根拠

ORDレコード
ord-de90db20102548c4abaeab3708d10805
出典データセット
uspto-grants-2013_04
特許番号
US08415369B2

反応ノート

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