Lithium Bromide → 1-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one
反応式
Cl[CH2:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12].[Br-:14].[Li+]>CC(C)=O>[Br:14][CH2:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12]参加物
4
実験手順
The compound of step 1 (3.20 g, 15.95 mmol) was dissolved in acetone (70 ml), and lithium bromide (11.08 g, 127.59 mmol) was added. The mixture was stirred overnight. The solvent was evaporated, the resulting solid was dissolved in EA and the solution washed twice with water followed by a saturated solution of sodium chloride, dried over sodium sulfate, filtered and evaporated to dryness. 3.66 g of the title compound were obtained as a white powder.
後処理
- customThe solvent was evaporated
- dissolutionthe resulting solid was dissolved in EA
- washthe solution washed twice with water
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-0017813294b64f21afa9f508a322291c
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415336B2
反応ノート
読み込み中…