4-Bromo-2-fluorobenzene-1-sulfonyl chloride → 4-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

HRID 1963663ノート

反応式

HRID 1963663 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1>[Fe](Cl)(Cl)Cl.C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1

参加物

4

反応物 1

HCID 27363104-Bromo-2-fluorobenzene-1-sulfonyl chloride

生成物 1

HCID 673740874-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

試薬・触媒・溶媒 2

HCID 24380Iron chloride (FeCl3)触媒HCID 241Benzene溶媒

実験手順

4-Bromo-2-fluoro-benzenesulfonyl chloride (2 g), benzene (1.3 ml) and iron (III) chloride (35 mg) were heated in a sealed tube using a microwave at 200 Watts for 15 seconds. After cooling purification by flash column chromatography (eluent 20% EtOAc/Hexane) gave the subtitle compound as a solid, yield 1.8 g.

後処理

  1. customfor 15 seconds
  2. temperatureAfter cooling
  3. custompurification by flash column chromatography (eluent 20% EtOAc/Hexane)

出典と根拠

ORDレコード
ord-4f57d37d7db74b53af693620025f26bf
出典データセット
uspto-grants-2013_04
特許番号
US08415394B2

反応ノート

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