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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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Potassium Carbonate → Isohexane ethyl acetate

HRID 1963678
ノート
印刷プレビュー

反応式

HRID 1963678 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:18]2[C:19]([OH:25])=[CH:20][CH:21]=[C:22]([F:24])[CH:23]=2)[CH:5]=[CH:6][C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[F:17])(=[O:10])=[O:9].CC1C=CC(S([O:36][C@H:37]([CH3:42])[C:38]([O:40]C)=[O:39])(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C.O>[CH3:7][CH2:2][CH2:3][CH:4]([CH3:18])[CH3:5].[C:37]([O:25][CH2:19][CH3:20])(=[O:36])[CH3:38].[F:1][C:2]1[CH:3]=[C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25][C@@H:37]([CH3:42])[C:38]([OH:40])=[O:39])[CH:5]=[CH:6][C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[F:17])(=[O:10])=[O:9]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 11430Potassium CarbonateHCID 12884153(R)-2-Tosyloxypropionic acid methyl esterHCID 672415383',5-Difluoro-4'-[(2-fluorophenyl)sulfonyl]biphenyl-2-ol

生成物 2

HCID 21882781Isohexane ethyl acetateHCID 57572452(2s)-2-({3',5-Difluoro-4'-[(2-fluorophenyl)sulfonyl]biphenyl-2-yl}oxy)propanoic acid

試薬・触媒・溶媒 2

HCID 962
Water
溶媒
HCID 6342Acetonitrile溶媒

反応条件

温度
65 °C

実験手順

The product of step (v) (175 mg), the product of step (vi) (124 mg) and potassium carbonate (133 mg) in acetonitrile (10 ml) were charged to a flask and stirred at 65° C. overnight. The reaction mixture was cooled, diluted with water (20 ml) and extracted with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane then 4:1 isohexane/ethyl acetate to give the sub-title compound as a colourless oil, yield 121 mg.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with diethyl ether
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by chromatography on silica eluting with isohexane

出典と根拠

ORDレコード
ord-4dc2a46f59284d99b1d3638117815cec
出典データセット
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08415394B2

反応ノート

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