Iodoethane → 1-Ethylpiperidine-4-carboxylic acid

HRID 1963700

反応式

HRID 1963700 の反応式
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.I[CH2:13][CH3:14].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH2:13]([N:9]1[CH2:8][CH2:7][CH:6]([C:4]([OH:3])=[O:5])[CH2:11][CH2:10]1)[CH3:14]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 70770Ethyl 4-piperidinecarboxylate

生成物 1

HCID 187837731-Ethylpiperidine-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To ethylpiperidine-4-carboxylate (1 eq) in ethanol was added iodoethane (1.1 eq) and potassium carbonate (2 eq) and the resulting mixture was refluxed for 16 h. The mixture was then cooled to room temperature and filtered. Ethanol was concentrated and partitioned between methylene chloride and water. The organic layer was then washed with saturated sodium chloride solution, dried with sodium sulfate and concentrated. To it was then added concentrated hydrochloric acid and water (2:1) and the mixture was refluxed for 5 h. The resulting 1-(ethyl)piperidine-4-carboxylic acid was then azeotroped with toluene. MS: MH+=158.

後処理

  1. temperaturethe resulting mixture was refluxed for 16 h
  2. filtrationfiltered
  3. concentrationEthanol was concentrated
  4. custompartitioned between methylene chloride and water
  5. washThe organic layer was then washed with saturated sodium chloride solution
  6. dry with materialdried with sodium sulfate
  7. concentrationconcentrated
  8. additionTo it was then added concentrated hydrochloric acid and water (2:1)
  9. temperaturethe mixture was refluxed for 5 h
  10. customThe resulting 1-(ethyl)piperidine-4-carboxylic acid was then azeotroped with toluene

出典と根拠

ORDレコード
ord-360b3805a976473bbc9dc1131933b8a2
出典データセット
uspto-grants-2013_04
特許番号
US08415382B2

関連ノート

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