Hydrochloric Acid → HCID 67020462、化合物

HRID 1963803ノート

反応式

HRID 1963803 の反応式
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20]>[OH-].[Na+]>[ClH:20].[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 18997131HCID 18997131、化合物

生成物 1

HCID 67020462HCID 67020462、化合物

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A suspension of 1-(2-phenylethyl)-4-carbetoxypiperidine (12.2 g, 0.047 mol) obtained as described in J. Med. Chem. 1996 (39), 749-756, in 1N NaOH (100 ml) was heated under reflux for 4 h. After cooling to room temperature, the solution was made acid with 6N HCl to pH 2, concentrated by evaporation at reduced pressure, and the solid thus obtained was filtered and dried in a stove under vacuum to give the desired product (12.1 g),

後処理

  1. customobtained
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated by evaporation at reduced pressure
  4. customthe solid thus obtained
  5. filtrationwas filtered
  6. customdried in a stove under vacuum

出典と根拠

ORDレコード
ord-d308e8a1450248f09072ba60de7b5939
出典データセット
uspto-grants-2013_04
特許番号
US08415476B2

反応ノート

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