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Trifluoroacetic acid → Methyl-{1-[2-methyl-1-(6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-propylcarbamoyl]-ethyl}-carbamic acid benzyl ester

HRID 1965165
ノート
印刷プレビュー

反応式

HRID 1965165 の反応式
C(OC([N:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]2[N:20]([C:23](=[O:45])[CH:24]([NH:28][C:29](=[O:44])[CH:30]([N:32]([C:34]([O:36][CH2:37][C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)=[O:35])[CH3:33])[CH3:31])[CH:25]([CH3:27])[CH3:26])[CH2:21][CH2:22][CH:9]12)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:37]([O:36][C:34](=[O:35])[N:32]([CH3:33])[CH:30]([C:29](=[O:44])[NH:28][CH:24]([C:23]([N:20]1[CH2:21][CH2:22][CH:9]2[NH:8][CH2:12][CH:11]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:10]12)=[O:45])[CH:25]([CH3:27])[CH3:26])[CH3:31])[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 676088904-{2-[2-(Benzyloxycarbonyl-methyl-amino)-propionylamino]-3-methyl-butyryl}-3-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

生成物 1

HCID 67608270Methyl-{1-[2-methyl-1-(6-phenoxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-propylcarbamoyl]-ethyl}-carbamic acid benzyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution containing 16 (370 mg, 0.59 mmol) in DCM (10 mL) was added TFA (4 mL) at 0° C. After 1 h, the reaction mixture was diluted with DCM and the resultant organic solution was washed successively with saturated aqueous NaHCO3 and brine, dried over anhydrous Na2SO4, filtered, and concentrated to afford crude 18 which was used without further purification.

後処理

  1. washthe resultant organic solution was washed successively with saturated aqueous NaHCO3 and brine
  2. dry with materialdried over anhydrous Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customto afford crude 18 which
  6. customwas used without further purification

出典と根拠

ORDレコード
ord-0045ef04a9464d998ba1774661abd126
出典データセット
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08415486B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート