Thionyl Chloride → HCID 67358175、化合物
反応式
[F:1][C:2]1[C:3]([CH2:9]O)=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.S(Cl)([Cl:13])=O>ClCCl.CN(C)C=O>[ClH:13].[Cl:13][CH2:9][C:3]1[C:2]([F:1])=[CH:7][C:6]([F:8])=[CH:5][N:4]=1参加物
5
実験手順
To a solution of (3,5-difluoropyridin-2-yl)methanol (Almedia et al., WO 08/117,050) (2.15 g, 14.8 mmol) in dichloromethane (20 mL) at 0° C. was added N,N-dimethylformamide (2 drops) and thionyl chloride (2.0 mL, 27 mmol). The solution was stirred at ambient temperature for 1 h and concentrated in vacuo to afford 2-(chloromethyl)-3,5-difluoropyridine hydrochloride (2.31 g, 78%) as a brown oil: Rf=0.71 (EtOAc/Hexanes, 1/1).
後処理
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-8a05cbad17cc46ddb601390615ae8a21
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415370B2
反応ノート
読み込み中…