Tetrahydrofuran → N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

HRID 1965944ノート

反応式

HRID 1965944 の反応式
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14]Cl.C(=O)(O)[O-].[Na+].O1CCCC1>CO>[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 758862-chloro-N,N-dimethylacetamideHCID 143276Methyl[2-(pyridin-4-yl)ethyl]amineHCID 516892Sodium Bicarbonate

生成物 1

HCID 21081298N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-[2-(methylamino)ethyl]pyridine (34.4 g) and 29.18 g of chloroacetic acid-dimethylamide are dissolved in 200 ml of methanol. After the addition of 20 g of sodium bicarbonate the mixture is refluxed for 5 hours with stirring. For working up the mixture is combined with 1000 ml of tetrahydrofuran, decanted off from the precipitated salts and the solution is filtered through active charcoal. After the limination of the solvent, N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide is obtained as a crude product.

後処理

  1. temperatureis refluxed for 5 hours
  2. customdecanted off from the precipitated salts
  3. filtrationthe solution is filtered through active charcoal

出典と根拠

ORDレコード
ord-b2be16b18a5f48e1b6b82760038f2a74
出典データセット
uspto-grants-2013_04
特許番号
US08420630B2

反応ノート

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