Tetrahydrofuran → Tert-butyl 4-(4-chloro-3-methoxyphenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carboxylate

反応式

[Br:1][c:2]1[cH:3][cH:4][c:5]([Cl:10])[c:6]([O:8][CH3:9])[cH:7]1.[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:16][C:17]1([CH3:31])[CH2:18][N:19]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:20][CH2:21][C:22]1=[O:23]>>[c:2]1([C:22]2([OH:23])[C:17]([CH3:16])([CH3:31])[CH2:18][N:19]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:20][CH2:21]2)[cH:3][cH:4][c:5]([Cl:10])[c:6]([O:8][CH3:9])[cH:7]1