Methyl 5-amino-2-(4-fluoro-2-hydroxyphenyl)-3-methylbenzoate → 8-Amino-3-fluoro-10-methylbenzo[c]chromen-6-one
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH3:20])[C:5]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=2[OH:19])=[C:6]([CH:11]=1)[C:7](OC)=[O:8]>N1C=CC=CC=1>[NH2:1][C:2]1[CH:3]=[C:4]([CH3:20])[C:5]2[C:12]3[C:13](=[CH:14][C:15]([F:18])=[CH:16][CH:17]=3)[O:19][C:7](=[O:8])[C:6]=2[CH:11]=1参加物
3
実験手順
Methyl 5-amino-2-(4-fluoro-2-hydroxyphenyl)-3-methylbenzoate (Reference Compound No. 1-4-(5), 7.40 g, 26.9 mmol) was dissolved in pyridine (250 mL) and then the reaction mixture was refluxed overnight. The reaction mixture was concentrated under reduced pressure, then ethyl acetate-hexane (1:1) was added to the obtained residue, and then filtered to give the titled reference compound (6.15 g) as a pale yellow solid. (Yield 94%)
後処理
- temperaturethe reaction mixture was refluxed overnight
- concentration