Nitric Acid → 4-Bromo-2-fluoro-5-nitrobenzaldehyde

HRID 1966311ノート

反応式

HRID 1966311 の反応式
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[C:8]([F:14])[CH:7]=1>S(=O)(=O)(O)O>[Br:5][C:6]1[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:9]([CH:10]=[O:11])=[C:8]([F:14])[CH:7]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 1435174-Bromo-2-fluorobenzaldehyde

生成物 1

HCID 184555954-Bromo-2-fluoro-5-nitrobenzaldehyde

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

Nitric acid (25 mL) is added dropwise to a solution of 4-bromo-2-fluorobenzaldehyde (5.12 g, 25.2 mmol) in sulfuric acid (25 mL). The mixture is stirred for 2 hours and then is poured over ice. Product is extracted into MTBE (100 mL). The organic layer is washed with saturated aqueous NaHCO3 (100 mL), dried (Na2SO4), and evaporated yielding 5.98 g of yellow solid. 1H NMR (DMSO-d6) δ 10.13, 8.49, 8.22.

後処理

  1. additionis poured over ice
  2. extractionProduct is extracted into MTBE (100 mL)
  3. washThe organic layer is washed with saturated aqueous NaHCO3 (100 mL)
  4. dry with materialdried (Na2SO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-80c90b47904e42f0a92f4d2eb3cfc562
出典データセット
uspto-grants-2013_04
特許番号
US08420646B2

反応ノート

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