P,P-Diphenylphosphinic azide → HCID 46198601、化合物

反応式

[CH2:1]([NH:8][C:9]1[CH:17]=[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][NH:33][CH3:34].C1COCC1.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=O)C=CC=CC=1>C1COCC1>[CH2:1]([NH:8][C:9]1[CH:17]=[C:16]([N:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:22][CH2:23]2)[CH:15]=[CH:14][C:10]=1[C:11]([N:33]([CH3:34])[CH3:32])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

実験手順

A solution of 2-(benzylamino)-4-(4-benzoylpiperazin-1-yl)benzoic acid (80 mg, 0.2 mmol), 2 M dimethylamine THF solution (0.38 ml, 0.78 mmol), tiethylamine (0.08 ml, 0.57 mmol) and diphenylphosphoryl azide (0.045 ml, 0.2 mmol) in 15 ml THF was stirred for 16 hours. The run was quenched with 1 ml water and all the solvents were evaporated under vacuum. 2-(benzylamino)-N,N-dimethyl-4-(4-benzoylpiperazin-1-yl)benzamide (50 mg, 60%) was obtained by flash column chromatograph (60% ethyl acetate in hexanes). 1H NMR (500 MHz, DMSO-d6) δ (ppm) 2.95 (d, 6H), 3.15-3.20 (s, br, 4H), 3.62 (s, br, 2H), 3.70 (s, br, 2H), 4.38 (d, 2H), 6.22 (d, J=2.2 Hz, 1H), 6.24 (dd, J=2.2, 8.3 Hz, 1H), 7.00 (dd, J=2.5, 8.4 Hz, 1H), 7.32-7.48 (m, 10H), 8.82 (s, 1H). 13C NMR (125 MHz, CDCl3): δ (ppm) 30.1, 30.8, 48.1, 48.9, 49.4, 99.5, 103.7, 111.1, 120.7, 126.6, 127.6, 127.7, 129.0, 129.1, 130.3, 130.5, 130.6, 136.0, 139.6, 149.5, 153.4, 170.8, 172.3.