Water → 2-Pyrimidinebutanal, 4-(trifluoromethyl)-
反応式
[CH2:1]([C:6]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][N:7]=1)[CH2:2][CH2:3][CH:4]=C.[OH2:16]>C1COCC1.O.O=[Os](=O)(=O)=O>[F:13][C:12]([F:15])([F:14])[C:10]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:1][CH2:2][CH2:3][CH:4]=[O:16])[N:11]=1参加物
5
実験手順
To a solution of 2-(4-penten-1-yl)-4-(trifluoromethyl)pyrimidine (P7, 143 mg) in THF/H2O 5/1 (6.5 mL) were added OsO4 (4% in water, 0.2 mL) and NaIO4 (424 mg). The solution was stirred at r.t. for 30 min. Water was then added and the mixture extracted with DCM. The organic phase was washed with brine, dried over Na2SO4, filtered and evaporated in vacuo to give 91 mg of the title compound as an oil, which was used in the subsequent step without further purification.
後処理
- extractionthe mixture extracted with DCM
- washThe organic phase was washed with brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-e71696faeb264609a77adf5a3a35f374
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745458B2
反応ノート
読み込み中…