HCID 58542057、化合物 → HCID 58541981、化合物
反応式
[CH:1]([C:4]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:15][OH:16])[O:6][N:5]=1)([CH3:3])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH:1]([C:4]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH:15]=[O:16])[O:6][N:5]=1)([CH3:3])[CH3:2]参加物
4
実験手順
To a solution of [2-(3-isopropyl-1,2,4-oxadiazol-5-yl)-phenyl]methanol (373 mg, 1.71 mmol) in CH2Cl2 (5.0 mL) is added MnO2 (300 mg, 3.45 mmol). The reaction mixture is stirred at room temperature for 48 hours and is filtered through diatomaceous earth. The filtrate is concentrated under reduced pressure and the residue is purified by silica gel flash column chromatography with 30% EtOAc in heptanes as the eluent to afford 2-(3-isopropyl-1,2,4-oxadiazol-5-yl)-benzaldehyde (139 mg, 37%).
後処理
- filtrationis filtered through diatomaceous earth
- concentrationThe filtrate is concentrated under reduced pressure
- customthe residue is purified by silica gel flash column chromatography with 30% EtOAc in heptanes as the eluent
出典と根拠
- ORDレコード
- ord-8ea8591ca03743d2a4cd34f4d01204a7
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420655B2
反応ノート
読み込み中…