反応式
[CH2:1]=[C:2]1[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH:7]1([NH:13][C:14]2[C:19]([CH:20]=[N:21][OH:22])=[CH:18][N:17]=[C:16]3[N:23]([CH2:26][CH3:27])[N:24]=[CH:25][C:15]=23)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.Cl[O-].[Na+]>O1CCCC1>[CH:7]1([NH:13][C:14]2[C:15]3[CH:25]=[N:24][N:23]([CH2:26][CH3:27])[C:16]=3[N:17]=[CH:18][C:19]=2[C:20]2[CH2:1][C:2]3([CH2:6][CH2:5][CH2:4][CH2:3]3)[O:22][N:21]=2)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
Methylene cyclopentane (0.073 ml, 0.0006 mole) was added to 4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde oxime (0.1 gm, 0.0003 mole) (example 8) in tetrahydrofuran. The reaction mixture was stirred at room temperature for about 5 minutes. Sodium hypochlorite (5 ml) was added slowly to the reaction mixture over a period of about 5 minutes and the mixture was allowed to stir at room temperature for about 5 h. The organic solvent was evaporated and the residue was extracted in ethyl acetate. The organic layer was concentrated and the title compound obtained was purified by preparative thin layer chromatography.
後処理
- stirringto stir at room temperature for about 5 h
- customThe organic solvent was evaporated
- extractionthe residue was extracted in ethyl acetate
- concentrationThe organic layer was concentrated
出典と根拠
- ORDレコード
- ord-b2cfe999cb0542a99f581d538ad50ca5
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420666B2
関連ノート
読み込み中…