Pyridine → N-(4-bromo-3-chloro-2-fluorophenyl)acetamide

HRID 1967315ノート

反応式

HRID 1967315 の反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[C:3]=1[Cl:10].[C:11](OC(=O)C)(=[O:13])[CH3:12].N1C=CC=CC=1>C(OCC)(=O)C>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11](=[O:13])[CH3:12])=[C:4]([F:9])[C:3]=1[Cl:10]

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 27827054-Bromo-3-chloro-2-fluoroaniline

生成物 1

HCID 23273791N-(4-bromo-3-chloro-2-fluorophenyl)acetamide収率 96%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a solution of 4-bromo-3-chloro-2-fluoroaniline (15.0 g) in ethyl acetate (200 mL) was added dropwise acetic anhydride (7.57 mL) at 0° C. Then, pyridine (10.8 mL) was added dropwise, and the mixture was stirred at room temperature overnight. The mixture was diluted with ethyl acetate, washed with water and saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained solid was washed with hexane to give the title compound as a colorless solid (yield: 17.1 g, 96%).

後処理

  1. washwashed with water and saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. washThe obtained solid was washed with hexane

出典と根拠

ORDレコード
ord-cfa4ece443a64a96a7cf4d955a7eaaa4
出典データセット
uspto-grants-2013_04
特許番号
US08420694B2

反応ノート

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