Acetic Acid → 2-chloro-4-[(2S,3S,4S)-3-hydroxy-2-methyl-4-(2-methylprop-2-en-1-yl)-5-oxopyrrolidin-1-yl]benzonitrile

温度

-78 °C

A solution of diisopropylamine (0.300 mL) in THF (15 mL) was cooled to −78° C., and n-butyllithium-hexane solution (1.26 mL, 1.6 mol/L) was added dropwise. After the completion of the dropwise addition, the mixture was stirred at −78° C. for 1 hr. Subsequently, a solution of 2-chloro-4-[(2S,3S)-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile (200 mg) in THF (4.0 mL) was added dropwise, and the mixture was further stirred at −78° C. for 1 hr. 3-Bromo-2-methylpropene (0.10 mL) was added dropwise at −78° C., and the mixture was further stirred at −78° C. to −10° C. for 1 hr. Acetic acid (1.0 mL) was added to the reaction mixture, and the mixture was warmed to room temperature. Water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=30/1→1/2) to give the title compound as a colorless solid (yield: 111.8 mg, 46.1%).

1. additionn-butyllithium-hexane solution (1.26 mL, 1.6 mol/L) was added dropwise
2. additionAfter the completion of the dropwise addition
3. stirringthe mixture was further stirred at −78° C. for 1 hr
4. stirringthe mixture was further stirred at −78° C. to −10° C. for 1 hr
5. temperaturethe mixture was warmed to room temperature
6. extractionthe mixture was extracted with ethyl acetate
7. washThe extract was washed with saturated brine
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationconcentrated under reduced pressure
10. customThe residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=30/1→1/2)

ORDレコード

ord-552183f961904d248295e1e734d0d28a

出典データセット

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08420694B2