Chlorotrimethylsilane → HCID 66905089、化合物

HRID 1967471ノート

反応式

HRID 1967471 の反応式
Cl.[NH2:2][CH2:3][CH2:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7].[CH3:15][Si]([Cl:19])(C)C>CO>[ClH:19].[NH2:2][CH2:3][CH2:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([O:8][CH3:15])=[O:7]

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 468640804-Amino-2-phenylbutanoic acid--hydrogen chloride (1/1)

生成物 1

HCID 66905089HCID 66905089、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

A mixture of 1 g (4.64 mmol) of 4-amino-2-phenylbutyric acid hydrochloride and 0.67 ml (5.1 mmol) of trimethylsilyl chloride in 50 ml of methanol is heated at reflux for 2 hours. The mixture is subsequently stirred at 20° C. for 12 hours and then concentrated under reduced pressure, triturated in 50 ml of ethyl ether and then filtered. This gives 0.9 g of the expected product in the form of a white solid.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 2 hours
  3. concentrationconcentrated under reduced pressure
  4. customtriturated in 50 ml of ethyl ether
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-fe0c8b4ec94c4b0cbdecd1a9f1efb16d
出典データセット
uspto-grants-2013_04
特許番号
US08420817B2

反応ノート

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