Trifluoroacetic acid → HCID 86654209、化合物

HRID 1968274ノート

反応式

HRID 1968274 の反応式
C([O:5][C:6](=[O:32])[C@H:7]([NH:10][CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[N:18](C(OC(C)(C)C)=O)[CH:19]=[C:20]([C:21]([O:23][CH3:24])=[O:22])[C:13]=12)[CH2:8][CH3:9])(C)(C)C.[C:33]([OH:39])([C:35]([F:38])([F:37])[F:36])=[O:34]>C(Cl)Cl>[F:36][C:35]([F:38])([F:37])[C:33]([OH:39])=[O:34].[CH3:24][O:23][C:21]([C:20]1[C:13]2[C:14](=[N:15][CH:16]=[CH:17][C:12]=2[CH2:11][NH:10][C@H:7]([CH2:8][CH3:9])[C:6]([OH:32])=[O:5])[NH:18][CH:19]=1)=[O:22]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 58293538HCID 58293538、化合物

生成物 1

HCID 86654209HCID 86654209、化合物収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a 100 mL round bottom flask equipped for stirring was added (R)-1-tert-butyl 3-methyl 4-((1-tert-butoxy-1-oxobutan-2-ylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate (1.45 g, 3.24 mmol) and DCM (10 mL). TFA (10 mL) was added and the reaction mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated and dried in vacuo to afford the title compound as a yellow oil (1.3 g, 99%) (TFA salt). [M+H] calc'd for C14H17N3O4, 292; found, 292.6.

後処理

  1. customTo a 100 mL round bottom flask equipped
  2. stirringthe reaction mixture was stirred at room temperature for 30 min
  3. concentrationThe reaction mixture was concentrated
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-55832bbc04f14476801b0b97c08aa18e
出典データセット
uspto-grants-2013_04
特許番号
US08420816B2

反応ノート

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