Sodium hydride → 2-Chloro-3-(5-(methylthio)-1,3,4-thiadiazol-2-ylthio)pyrazine
反応式
[CH3:1][S:2][C:3]1[S:7][C:6]([SH:8])=[N:5][N:4]=1.[H-].[Na+].Cl[C:12]1[C:17]([Cl:18])=[N:16][CH:15]=[CH:14][N:13]=1>CN(C=O)C.C1C=CC=CC=1>[Cl:18][C:17]1[C:12]([S:8][C:6]2[S:7][C:3]([S:2][CH3:1])=[N:4][N:5]=2)=[N:13][CH:14]=[CH:15][N:16]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
The title compound was prepared according the procedure described in Example 1 by using 5-(methylthio)-1,3,4-thiadiazole-2-thiol (1.64 g, 10.00 mmol), NaH (60% dispersion in mineral oil, 445 mg, 11.00 mmol), and 2,3-dichloropyrazine (1.04 ml, 10.00 mmol) in DMF and benzene (12 ml, 1/1) by stirring at 50° C. for 20 hr and then at 110° C. for 4 hr under nitrogen atmosphere.
後処理
- waitat 110° C. for 4 hr under nitrogen atmosphere
出典と根拠
- ORDレコード
- ord-c321426676554518839d89780344a019
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08426358B2
反応ノート
読み込み中…