2-(4-Nitro-1H-pyrazol-1-yl)ethan-1-ol → 2-(4-Amino-1H-pyrazol-1-yl)ethanol

HRID 1968518ノート

反応式

HRID 1968518 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][OH:11])[CH:8]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][OH:11])[CH:8]=1

参加物

4

反応物 1

HCID 1620552-(4-Nitro-1H-pyrazol-1-yl)ethan-1-ol

生成物 1

HCID 284922672-(4-Amino-1H-pyrazol-1-yl)ethanol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 2-(4-nitro-1H-pyrazol-1-yl)ethanol (1.08 g, 6.87 mmol) in methanol (34 ml) was evacuated and purged with nitrogen and treated with palladium on carbon (0.1 g, 0.094 mmol). The resulting black suspension was evacuated and purged with a hydrogen balloon and stirred under hydrogen overnight. The mixture was filtered through celite with methanol washes, and concentrated. The residue was flash chromatographed (50 mm; 9% methanol/methylene chloride w/0.1% NH4OH then 10% methanol/methylene chloride w/0.1% NH4OH) to afford the title compound.

後処理

  1. custompurged with nitrogen
  2. customThe resulting black suspension was evacuated
  3. custompurged with a hydrogen balloon
  4. filtrationThe mixture was filtered through celite with methanol washes
  5. concentrationconcentrated
  6. customchromatographed (50 mm

出典と根拠

ORDレコード
ord-2a0a196daeb74c7eb9b5aced72273814
出典データセット
uspto-grants-2013_04
特許番号
US08426408B2

反応ノート

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