N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide → 2-(4-amino-1H-pyrazol-1-yl)-N,N-dimethylacetamide

HRID 1968526ノート

反応式

HRID 1968526 の反応式
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[CH2:4][N:5]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[N:6]1>CO.[Pd]>[NH2:10][C:8]1[CH:7]=[N:6][N:5]([CH2:4][C:3]([N:2]([CH3:14])[CH3:1])=[O:13])[CH:9]=1

参加物

4

反応物 1

HCID 60729245N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide

生成物 1

HCID 282806662-(4-amino-1H-pyrazol-1-yl)-N,N-dimethylacetamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide (870 mg, 4.39 mmol) in methanol (22 ml) was evacuated/purged with nitrogen and treated with Pd on carbon (87 mg, 0.082 mmol). The resulting black suspension was evacuated/purged with a hydrogen balloon and stirred under the hydrogen overnight when the mixture was filtered through celite with methanol washes. The filtrate was concentrated to give the product.

後処理

  1. customThe resulting black suspension was evacuated/purged with a hydrogen balloon
  2. filtrationwas filtered through celite with methanol washes
  3. concentrationThe filtrate was concentrated
  4. customto give the product

出典と根拠

ORDレコード
ord-040b4427d31d498e92aa03cda395dbae
出典データセット
uspto-grants-2013_04
特許番号
US08426408B2

反応ノート

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