Sodium borohydride → 7-methoxy-3H-isobenzofuran-1-one

HRID 1968765ノート

反応式

HRID 1968765 の反応式
[BH4-].[Na+].C(N(CC)[C:6](=[O:17])[C:7]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[CH:9][C:8]=1[CH:15]=[O:16])C>CO>[CH3:14][O:13][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:7]=1[C:6](=[O:17])[O:16][CH2:15]2

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 12460617N,N-Diethyl-2-formyl-6-methoxybenzamide

生成物 1

HCID 109865837-methoxy-3H-isobenzofuran-1-one収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

Solid sodium borohydride (14.02 g, 370.5 mmol, 1.75 equiv) was added in portions to a solution of N,N-diethyl-2-formyl-6-methoxy-benzamide (49.81 g, 211.7 mmol) in methanol (800 ml) at 0° C. After complete addition, stirring was continued at room temperature for 30 minutes, until TLC analysis indicated complete consumption of starting material. The reaction mixture was cooled to 0° C., and 6N aqueous HCl (134 ml) was carefully added. The solution was heated to 90° C. for 90 minutes. After cooling, volatiles were removed in vacuo. The residue was taken up in water (500 ml) and extracted four times with EtOAc (1.6 liter in total). The combined organic layers were washed with brine (2×100 ml), dried over Na2SO4, filtered and concentrated in vacuo to afford the title compound (33.92 g, 98%) in adequate purity for direct use in the next transformation. 1H NMR (400 MHz, CDCl3): δ=7.60 (t, J=8.4 Hz, 1H), 7.00 (d, J=7.6 Hz, 1H), 6.91 (d, J=8.3 Hz, 1H), 5.22 (s, 2H), 3.98 (s, 3H). MS (ES+): 165 (M+H)+.

後処理

  1. additionAfter complete addition
  2. customconsumption of starting material
  3. addition6N aqueous HCl (134 ml) was carefully added
  4. temperatureThe solution was heated to 90° C. for 90 minutes
  5. temperatureAfter cooling
  6. customvolatiles were removed in vacuo
  7. extractionextracted four times with EtOAc (1.6 liter in total)
  8. washThe combined organic layers were washed with brine (2×100 ml)
  9. dry with materialdried over Na2SO4
  10. filtrationfiltered
  11. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f1bab4ac55304ae6b19cb939febaa226
出典データセット
uspto-grants-2013_04
特許番号
US08426440B2

反応ノート

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