Nitric Acid → 2-Fluoro-4-methyl-6-nitrophenol

HRID 1968955ノート

反応式

HRID 1968955 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11]>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[OH:9]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 27784852-Fluoro-4-methylphenol

生成物 1

HCID 227538152-Fluoro-4-methyl-6-nitrophenol収率 59%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 2-fluoro-4-methylphenol (500 mg, 3.96 mmol) in dichloromethane (5 mL) at room temperature was added dropwise nitric acid 70% (0.4 mL, 4.44 mmol) [exotherm observed]. After 15 min more washed with water, dried, evaporated to give 2-fluoro-4-methyl-6-nitrophenol (400 mg, 2.337 mmol, 59.0% yield) as a yellow solid.

後処理

  1. washAfter 15 min more washed with water
  2. customdried
  3. customevaporated

出典と根拠

ORDレコード
ord-42841017916944a2b955aee437a38409
出典データセット
uspto-grants-2013_04
特許番号
US08426443B2

反応ノート

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