2,3-Difluoro-4-methyl-6-nitrophenol → 6-Amino-2,3-difluoro-4-methyl-phenol

HRID 1968958ノート

反応式

HRID 1968958 の反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[C:4]([N+:10]([O-])=O)[C:3]=1[OH:13].[H][H]>C(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[C:4]([NH2:10])[C:3]=1[OH:13]

参加物

5

反応物 2

HCID 594441602,3-Difluoro-4-methyl-6-nitrophenolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 594441706-Amino-2,3-difluoro-4-methyl-phenol収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 2,3-difluoro-4-methyl-6-nitrophenol (1.2 g, 6.35 mmol) (D44) in ethanol (120 mL) was hydrogenated using a 10% Pd/C cartridge in the H-cube™ hydrogenator at 1 mL/min and full hydrogen at 25° C. Evaporation gave 2,3-difluoro-4-methyl-6-aminophenol (1.0 g, 6.28 mmol, 99% yield) as a fawn solid.

後処理

  1. customat 25° C
  2. customEvaporation

出典と根拠

ORDレコード
ord-ffcce64ba1a6474780945b0edde08465
出典データセット
uspto-grants-2013_04
特許番号
US08426443B2

反応ノート

読み込み中…