4-Methyl-2-nitrobenzoic acid → (4-Methyl-2-nitrophenyl)methanol

HRID 1969004ノート

反応式

HRID 1969004 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1>O1CCCC1>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][OH:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

参加物

3

反応物 1

HCID 2550274-Methyl-2-nitrobenzoic acid

生成物 1

HCID 53405041(4-Methyl-2-nitrophenyl)methanol収率 98%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 4-methyl-2-nitrobenzoic acid (5 g, 27.6 mmol) in tetrahydrofuran (THF) (27 mL) was added borane tetrahydrofuran complex (35.9 mL, 35.9 mmol) and the mixture stirred at reflux for 3 hours. After cooling, the reaction mixture was extracted with water and DCM. The combined organic layers were dried over MgSO4 and then evaporated to dryness to give the alcohol (D139) as a pale yellow solid (4.52 g, 98%) which was used without further purification.

後処理

  1. temperatureat reflux for 3 hours
  2. temperatureAfter cooling
  3. extractionthe reaction mixture was extracted with water and DCM
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-cd0d636621cf4a10a9f4ea2c557b7737
出典データセット
uspto-grants-2013_04
特許番号
US08426443B2

反応ノート

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