Methyl triflate → 1-(3,3-difluoroazetidin-1-ylsulfonyl)-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate

HRID 1969513ノート

反応式

HRID 1969513 の反応式
[F:1][C:2]1([F:14])[CH2:5][N:4]([S:6]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)(=[O:8])=[O:7])[CH2:3]1.[F:15][C:16]([F:23])([F:22])[S:17]([O:20]C)(=[O:19])=[O:18]>C(Cl)Cl>[F:15][C:16]([F:23])([F:22])[S:17]([O-:20])(=[O:19])=[O:18].[F:14][C:2]1([F:1])[CH2:5][N:4]([S:6]([N:9]2[CH:13]=[CH:12][N+:11]([CH3:16])=[CH:10]2)(=[O:8])=[O:7])[CH2:3]1

参加物

4

反応物 2

HCID 9526Methyl triflateHCID 58557985HCID 58557985、化合物

生成物 1

HCID 866604301-(3,3-difluoroazetidin-1-ylsulfonyl)-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate収率 165.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 1-(3,3-difluoroazetidin-1-ylsulfonyl)-1H-imidazole (0.500 g, 2.24 mmol) in DCM (5 mL) at about 0° C. was added methyl trifluoromethanesulfonate (0.27 mL, 2.46 mmol) dropwise over about 3 min. The reaction mixture was stirred at about 0° C. for about 2 h. The solid was collected by vacuum filtration, washed with DCM (10 mL), and dried under vacuum to give 1-(3,3-difluoroazetidin-1-ylsulfonyl)-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate (0.79 g, 90%) as a white solid: LC/MS (Table 1, Method c) Rt=1.12 min; MS m/z 238 (M+H)+.

後処理

  1. filtrationThe solid was collected by vacuum filtration
  2. washwashed with DCM (10 mL)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-8d63c9db65304189b03d9a81bbb2a3af
出典データセット
uspto-grants-2013_04
特許番号
US08426411B2

反応ノート

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