3-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester → Butyl 3-aminopyrrolidine-1-carboxylate

HRID 1970473ノート

反応式

HRID 1970473 の反応式
[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH:13]C(OCC2C=CC=CC=2)=O)[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 668545503-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester

生成物 1

HCID 11608053Butyl 3-aminopyrrolidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 467 mg 3-benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester in 10 ml ethyl acetate was stirred in the presence of 50 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

後処理

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-5f9f7a17b08d4ee288852c9c73d4bca8
出典データセット
uspto-grants-2013_04
特許番号
US08426420B2

反応ノート

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