Trifluoroacetic acid → Benzyl 3-aminopyrrolidine-1-carboxylate
反応式
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH:13]([NH:16]C(OC(C)(C)C)=O)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>ClCCl>[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of 3.21 g 3-tert-butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester in 40 ml dichloromethane were added 13 ml TFA. After 16 h the solution was evaporated to give the crude hydrotrifluoroacetate. Yield: 3.20 g.
後処理
- customAfter 16 h the solution was evaporated
- customto give the crude hydrotrifluoroacetate
出典と根拠
- ORDレコード
- ord-8d72fa9f588b48b3a73b5e1fd787eac4
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08426420B2
反応ノート
読み込み中…