3-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester → Pyrrolidin-3-yl-carbamic acid butyl ester

HRID 1970478ノート

反応式

HRID 1970478 の反応式
C(OC([N:11]1[CH2:15][CH2:14][CH:13]([NH:16][C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:12]1)=O)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:20]([O:19][C:17](=[O:18])[NH:16][CH:13]1[CH2:14][CH2:15][NH:11][CH2:12]1)[CH2:21][CH2:22][CH3:23]

参加物

4

反応物 1

HCID 668544263-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester

生成物 1

HCID 20242877Pyrrolidin-3-yl-carbamic acid butyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 467 mg 3-butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester in 10 ml ethyl acetate was stirred in the presence of 100 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

後処理

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-bea721c1ac824d4b9b92af0dde2109ba
出典データセット
uspto-grants-2013_04
特許番号
US08426420B2

反応ノート

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