Trifluoroacetic acid → (R)-2-Methyl-piperazine-1-carboxylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][C@H:7]1[CH3:19])=[O:5])[CH3:2].C(O)(C(F)(F)F)=O>ClCCl>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][C@H:7]1[CH3:19])=[O:5])[CH3:2]参加物
4
実験手順
A solution of 2.05 g (R)-2-Methyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-ethyl ester in 15 ml dichloromethane was treated with 11.2 ml TFA and the resulting solution stirred for 12 h. The solvents were removed in vacuum and the crude hydrotrifluoroacetate transformed to the free amine by treatment with (Polystyrylmethyl)trimethylammonium bicarbonate in MeCN. Yield: 1.45 g.
後処理
- customThe solvents were removed in vacuum
出典と根拠
- ORDレコード
- ord-24372b3a29414b84b6a443bbe2afbaf8
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08426420B2
反応ノート
読み込み中…