Trifluoroacetic acid → (R)-benzyl 2-methylpiperazine-1-carboxylate

HRID 1970541ノート

反応式

HRID 1970541 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[C@H:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[CH3:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 53886770(R)-4-Boc-1-Cbz-2-methyl-piperazine

生成物 1

HCID 40424346(R)-benzyl 2-methylpiperazine-1-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 4.3 g (R)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 20 ml dichloromethane was stirred in the presence of 10 ml TFA for 16 h. The solution was concentrated and the residue codistilled twice with toluene to give the crude hydrotrifluoroacetate. Yield: 6.1 g.

後処理

  1. concentrationThe solution was concentrated
  2. customto give the crude hydrotrifluoroacetate

出典と根拠

ORDレコード
ord-6a23a07fcd1442c288ef8fb2314ac3c4
出典データセット
uspto-grants-2013_04
特許番号
US08426420B2

反応ノート

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