Trifluoroacetic acid → Phenyl piperazine-1-carboxylate
反応式
[C:1]1([O:7][C:8]([N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(C(F)(F)F)=O>ClCCl>[C:1]1([O:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
Crude piperazine-1,4-dicarboxylic acid tert-butyl ester phenyl ester was dissolved in 10 ml dichloromethane and treated with 4 ml TFA. After stirring for 12 h the solution was concentrated and the residue codistilled twice with toluene. Yield: 3.0 g.
後処理
- concentrationwas concentrated
出典と根拠
- ORDレコード
- ord-e7e491c331a6439296bf72d1f0a0e72f
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08426420B2
反応ノート
読み込み中…