(7R,8R)-N-benzyl-7-methyl-1,4-dioxaspiro[4.5]decan-8-amine → (7R,8R)-7-Methyl-1,4-dioxaspiro[4.5]decan-8-amine
反応式
C([NH:8][C@@H:9]1[CH2:18][CH2:17][C:12]2([O:16][CH2:15][CH2:14][O:13]2)[CH2:11][C@H:10]1[CH3:19])C1C=CC=CC=1>CO.[Pd]>[CH3:19][C@H:10]1[C@H:9]([NH2:8])[CH2:18][CH2:17][C:12]2([O:13][CH2:14][CH2:15][O:16]2)[CH2:11]1参加物
4
実験手順
A mixture of (7R,8R)—N-benzyl-7-methyl-1,4-dioxaspiro[4.5]decan-8-amine (640 mg, 2.4 mmol) and Pd/C (10%, 52 mg) in MeOH (50 mL) was left to stir under H2 (1 atm) overnight. The mixture was filtered through celite, and concentrated to afford the title compound. 1H NMR (600 MHz, CDCl3) δ 3.91 (m, 4H); 1.15-2.12 (series of m, 7H); 0.96 (d, 3H).
後処理
- waitwas left
- filtrationThe mixture was filtered through celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5b3f5bfa187543d7b7486c1d0ee848e4
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431569B2
反応ノート
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