Ammonium Chloride → 4-(Benzyloxy)-2-fluorocyclohexanol
反応式
[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11]([F:16])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].[Cl-].[NH4+]>CO.[Cl-].[Na+].O>[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([OH:15])[CH:11]([F:16])[CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
6
実験手順
To a stirred solution of 4-(benzyloxy)-2-fluorocyclohexanone (3.8 g, 17.1 mmol) in methanol (60 mL) was added sodium borohydride (1.29 g, 34.2 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature, and left to stir for 45 min. The reaction mixture was treated with ammonium chloride solution and brine, and extracted with EtOAc. The combined organics were dried (magnesium sulfate), and concentrated to afford the title compound.
後処理
- waitleft
- extractionextracted with EtOAc
- dry with materialThe combined organics were dried (magnesium sulfate)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a8140fedebcb464498345906b84fc9d9
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431569B2
反応ノート
読み込み中…