HCID 59543150、化合物 → 4-{[Tert-butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanol
反応式
C([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])[CH:11]([F:23])[CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[Si:16]([O:15][CH:12]1[CH2:13][CH2:14][CH:9]([OH:8])[CH2:10][CH:11]1[F:23])([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17]参加物
4
実験手順
To a stirred solution {[4-(benzyloxy)-2-fluorocyclohexyl]oxy}(tert-butyl)dimethylsilane (4.66 g, 13.8 mmol) in MeOH (30 mL) was added Pd(OH)2 in MeOH (20 mL). The flask was evacuated and filled with hydrogen several times, and left to stir overnight under hydrogen atmosphere. The mixture was diluted with DCM, filtered through a pad of Celite, and concentrated to afford the title compound.
後処理
- customThe flask was evacuated
- additionfilled with hydrogen several times
- waitleft
- additionThe mixture was diluted with DCM
- filtrationfiltered through a pad of Celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-869aa63bad364d6daf855a00922fe010
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431569B2
反応ノート
読み込み中…