HCID 59543137、化合物 → 4-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine

HRID 1970989ノート

反応式

HRID 1970989 の反応式
[N:1]([CH:4]1[CH2:9][CH2:8][CH:7]([O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])[CH:6]([F:18])[CH2:5]1)=[N+]=[N-]>CO.[Pd]>[Si:11]([O:10][CH:7]1[CH2:8][CH2:9][CH:4]([NH2:1])[CH2:5][CH:6]1[F:18])([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12]

参加物

4

反応物 1

HCID 59543137HCID 59543137、化合物

生成物 1

HCID 595431224-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

To a stirred solution [(4-azido-2-fluorocyclohexyl)oxy](tert-butyl)dimethylsilane (1.0 g, 3.66 mmol) in MeOH (15 mL) was added Pd/C in MeOH. The flask was evacuated and filled with hydrogen several times, and left to stir overnight under hydrogen atmosphere. The mixture was diluted with DCM, filtered through a pad of Celite, and concentrated to afford the title compound.

後処理

  1. customThe flask was evacuated
  2. additionfilled with hydrogen several times
  3. waitleft
  4. additionThe mixture was diluted with DCM
  5. filtrationfiltered through a pad of Celite
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-8bae95b7b94349f9b70c918431b8eece
出典データセット
uspto-grants-2013_04
特許番号
US08431569B2

反応ノート

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