N-Benzyloxycarbonyl-L-leucine-N-methylamide → (2S)-2-amino-N,4-dimethylpentanamide
反応式
[CH3:1][NH:2][C:3](=[O:20])[C@H:4]([CH2:16][CH:17]([CH3:19])[CH3:18])[NH:5]C(OCC1C=CC=CC=1)=O.[H][H]>[Pd].CO>[CH3:1][NH:2][C:3](=[O:20])[C@H:4]([CH2:16][CH:17]([CH3:19])[CH3:18])[NH2:5]参加物
5
実験手順
A mixture of intermediate 20A (1.20 g, 4.31 mmol) and 10% palladium on carbon (300 mg) in MeOH (30 mL) was hydrogenated with a Parr shaker under 55 psi of hydrogen gas for 3 h. After filtration through celite, the filtrate was evaporated and azeotroped with EtOAc to give the desired intermediate 20B as white solid (quant. yield). LCMS (+ESI) m/z 145.1 [M+H]+.
後処理
- filtrationAfter filtration through celite
- customthe filtrate was evaporated
- customazeotroped with EtOAc
出典と根拠
- ORDレコード
- ord-82c847de060945e497127c0b47b3ad01
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08431565B2
反応ノート
読み込み中…