Water → 2-Bromo-2-phenylacetamide

HRID 1971618

反応式

HRID 1971618 の反応式
[C:1]1([CH2:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:11]N1C(=O)CCC1=O.O>ClCCl>[Br:11][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:8]([NH2:10])=[O:9]

参加物

5

反応物 3

HCID 962WaterHCID 7680BenzeneacetamideHCID 67184N-bromobutanimide

生成物 1

HCID 2420282-Bromo-2-phenylacetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Benzeneacetamide (3.0 g, 0.022 mol) was dissolved in dichloromethane (60 mL) and N-bromosuccinimide (4.0 g, 0.022 mol) was added. The reaction was stirred at room temperature under UV light for 24 hr. The mixture was poured into water and the layers were separated. The organic layer was washed with water (2×50 mL) then with brine (1×50 mL). The organic layer was dried (magnesium sulfate) then chromatographed on silica (40% ethyl acetate/hexanes) to give 2-Bromo-2-phenylacetamide, compound h Rf 0.37, 40% ethyl acetate/hexanes; MS m/z 216 (M+H).

後処理

  1. customthe layers were separated
  2. washThe organic layer was washed with water (2×50 mL)
  3. dry with materialThe organic layer was dried (magnesium sulfate)
  4. customthen chromatographed on silica (40% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-bd79f96846d84017b4148134f41aa0d1
出典データセット
uspto-grants-2013_04
特許番号
US08431608B2

関連ノート

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