Water → 2-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)-2-phenylacetamide

HRID 1971619

反応式

HRID 1971619 の反応式
[H-].[Na+].[F:3][C:4]1[CH:5]=[CH:6][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[N:8][CH:9]=1.Br[CH:22]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:23]([NH2:25])=[O:24].O>CN(C)C=O>[F:3][C:4]1[CH:5]=[CH:6][C:7](=[N:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[N:8]([CH:22]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:23]([NH2:25])=[O:24])[CH:9]=1

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 2420282-Bromo-2-phenylacetamideHCID 57607460N-(5-fluoropyridin-2-yl)-4-methylbenzenesulfonamide

生成物 1

HCID 669921912-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)-2-phenylacetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

Sodium hydride (0.040 g, 0.0017 mol) was suspended in N,N-dimethylformamide (15 mL) and was cooled at 0° C. N-(5-fluoropyridin-2-yl)-4-methylbenzenesulfonamide (compound a, 0.37 g, 0.0014 mol) was added and was stirred for 15 minutes. 2-Bromo-2-phenylacetamide h (0.3 g, 0.001 mol) was added then the reaction was warmed to room temperature and was stirred for 24 hours. The reaction was poured into water and extracted with ethyl acetate (3×50 mL) then dried then chromatographed on silica (50% ethyl acetate/hexanes) to give 2-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)-2-phenylacetamide (compound j) Rf 0.42, 50% ethyl acetate/hexanes; MS m/z 400 (M+H).

後処理

  1. temperaturethe reaction was warmed to room temperature
  2. stirringwas stirred for 24 hours
  3. extractionextracted with ethyl acetate (3×50 mL)
  4. customthen dried
  5. customthen chromatographed on silica (50% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-1b30677c18f740e8b5b9b8347a7aa2a7
出典データセット
uspto-grants-2013_04
特許番号
US08431608B2

関連ノート

読み込み中…