Isopropylamine → Tert-butyl 2-(isopropylamino)ethyl(prop-2-ynyl)carbamate

HRID 1971675ノート

反応式

HRID 1971675 の反応式
CS(O[CH2:6][CH2:7][N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:9][C:10]#[CH:11])(=O)=O.[CH:19]([NH2:22])([CH3:21])[CH3:20]>>[CH:19]([NH:22][CH2:6][CH2:7][N:8]([CH2:9][C:10]#[CH:11])[C:12](=[O:13])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:21])[CH3:20]

参加物

3

反応物 2

HCID 6363IsopropylamineHCID 581248922-(Tert-butoxycarbonyl(prop-2-ynyl)amino)ethyl methanesulfonate

生成物 1

HCID 58124856Tert-butyl 2-(isopropylamino)ethyl(prop-2-ynyl)carbamate

実験手順

A solution of 900 mg of 10e in 15 ml of isopropyl amine was stirred for 3 days at RT. The reaction mixture was concentrated. The residue was treated with 10 ml of sat. NaHCO3 and extracted with ethyl acetate. After drying and concentration of the organic material 750 mg of essentially pure 10f was obtained as an oil.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionThe residue was treated with 10 ml of sat. NaHCO3
  3. extractionextracted with ethyl acetate
  4. customAfter drying

出典と根拠

ORDレコード
ord-d5805bf584344fd1ab24103e16635913
出典データセット
uspto-grants-2013_04
特許番号
US08431564B2

反応ノート

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