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Potassium Carbonate → HCID 58124874、化合物

HRID 1971681
ノート
印刷プレビュー

反応式

HRID 1971681 の反応式
Br[C:2]1[C:3]([O:37][CH3:38])=[CH:4][C:5]2[CH2:6][CH2:7][N:8]3[C:14]4[C:15](=[O:31])[N:16]([CH:28]([CH3:30])[CH3:29])[CH2:17][CH2:18][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:20][C:13]=4[C:12]([C:32]4[S:33][CH:34]=[CH:35][CH:36]=4)=[C:9]3[C:10]=2[CH:11]=1.[N:39]1[CH:44]=[CH:43][CH:42]=[C:41](B(O)O)[CH:40]=1.C([O-])([O-])=O.[K+].[K+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.COCCOC>[CH:28]([N:16]1[C:15](=[O:31])[C:14]2[N:8]3[CH2:7][CH2:6][C:5]4[CH:4]=[C:3]([O:37][CH3:38])[C:2]([C:41]5[CH:40]=[N:39][CH:44]=[CH:43][CH:42]=5)=[CH:11][C:10]=4[C:9]3=[C:12]([C:32]3[S:33][CH:34]=[CH:35][CH:36]=3)[C:13]=2[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:18][CH2:17]1)([CH3:30])[CH3:29]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 11430Potassium Carbonate2 回HCID 27343783-Pyridinylboronic acidHCID 58124866HCID 58124866、化合物

生成物 1

HCID 58124874HCID 58124874、化合物収率 93.6%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒
HCID 8071
1,2-Dimethoxyethane
溶媒

実験手順

A mixture of 60 mg of 10l, 22 mg of 3-pyridylboronic acid, 12 mg of Pd(PPh3)4 and 40 mg of K2CO3 in 3 ml of degassed 90% aq. DME was heated under N2 for 16 h. The reaction mixture was poured onto 1M K2CO3 solution and the product was extracted with ethyl acetate. The organic extract was washed once with sat. NaCl, dried and concentrated. The crude material thus obtained was chromatographed over silica gel, using heptane/acetone in a gradient. The isolated product was triturated with diethyl ether, to give 56 mg of 10m, Mp: 207-208° C.

後処理

  1. temperaturewas heated under N2 for 16 h
  2. extractionthe product was extracted with ethyl acetate
  3. extractionThe organic extract
  4. washwas washed once with sat. NaCl
  5. customdried
  6. concentrationconcentrated
  7. customThe crude material thus obtained
  8. customwas chromatographed over silica gel
  9. customThe isolated product was triturated with diethyl ether

出典と根拠

ORDレコード
ord-587ad52c644b420b9827c6f1461f39fc
出典データセット
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08431564B2

反応ノート

読み込み中…

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